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KMID : 1189420140270010058
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2014 Volume.27 No. 1 p.58 ~ p.67
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Effects of Lycii Fructus Extracts(LFE) on Skin whitening and Elasticity using Melanoma cells
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Choi Joo-Ho
Choi Jung-Hwa
Park Soo-Yeon
Kim Jong-Hwan
Jung Min-Young
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Abstract
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Objective : Lycii Fructus Extracts(LFE) can do Anti-hypertension activity, Antidepressant, Anti-diabetic activity. This study was designed to investigate effects of LFE on skin whitening and elasticity using melanoma cells.
Methods : In this experiment, effect of LFE on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase.
Results : More than $250{\mu}g/ml$ 수식 이미지 of LFE treated group showed lowered proliferation rates significantly compared to non-treated group. More than $125{\mu}g/ml$ 수식 이미지 of LFE treated groups were lower levels of melanin synthesis respectively. LFE showed inhibitory effect on tyrosinase activities in vitro. And, LFE suppressed tyrosinase activities in B16F10 cells significantly. Finally, LFE suppressed elastase type I and IV activities in dose-dependent manner in vitro. And LFE also slightly suppressed elastase activities in vivo.
Conclusion : These results suggest that LFE can inhibit melanin synthesis through ihhibitory action on tyrosinase activity and inhibt elastase activity, and also suggest that these results can be used for the study on maintaining skin elasticity or whitening.
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KEYWORD
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Lycii Fructus Extracts(LFE), Skin whitening, Skin Elasticity, Melanoma cell
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